Worldwide surveys on anaphylaxis to sublingual immunotherapy with house dust mite tablets are urgently needed.

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Worldwide surveys on anaphylaxis to sublingual immunotherapy with house dust mite tablets are urgently needed.

アブストラクト	In the 1980s, a global number of 72 fatalities were reported in the UK and the USA following the application of subcutaneous immunotherapy (SCIT). This resulted in a significant limitation of SCIT use and in the search of other routes of administration, among which sublingual immunotherapy (SLIT) showed the best balance between efficacy and safety. Data from controlled studies suggest that tablets-related anaphylaxis is an uncommon event. However, in the Eudravigilance (European database of suspected adverse drug reactions from Europe) we found reports of life-threatening events or severe local reactions under SLIT increasing over the last few years. Therefore, all efforts to minimize the related risk have to be strongly encouraged.
ジャーナル名	Clinical and translational allergy
投稿日	2021/4/27
投稿者	Mosges, Ralph; Passali, Desiderio; Di Gioacchino, Mario
組織名	IMSB (Institute of Computational Biology and Medical Statistics), University at;Cologne, Cologne, 50924, Germany.;Clinical Research International Limited, Muhlenberg 64, Hamburg, 22587, Germany.;Istituto di Discipline Otorinolarinogologiche, Universita degli Studi, Siena,;53100, Italy.;Department of Medicine and Science of Ageing, G. d'Annunzio University;Chieti-Pescara, Chieti, 66100, Italy.;Institute for Clinical Immunotherapy and Advanced Biological Treatments, Pescara,;65100, Italy.
Pubmed リンク	https://www.ncbi.nlm.nih.gov/pubmed/33900053/