| アブストラクト | Since 1996, the scientific community has become aware of 14 reports of yellow fever vaccine (YEL)-associated viscerotropic disease (YEL-AVD) cases and four reports of YEL-associated neurotropic disease (YEL-AND) worldwide, changing our understanding of the risks of the vaccine. Based on 722 adverse event reports after YEL submitted to the U.S. Vaccine Adverse Event Reporting System in 1990-2002, we updated the estimates of the age-adjusted reporting rates of serious adverse events, YEL-AVD and YEL-AND. We found that the reporting rates of serious adverse events were significantly higher among vaccinees aged > or =60 years than among those 19-29 years of age (reporting rate ratio = 5.9, 95% CI 1.6-22.2). Yellow fever is a serious and potentially fatal disease. For elderly travelers, the risk for severe illness and death due to yellow fever infection should be balanced against the risk of a serious adverse event due to YEL. |
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| 投稿日 | 2005/4/20 |
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| 投稿者 | Khromava, Alena Y; Eidex, Rachel Barwick; Weld, Leisa H; Kohl, Katrin S; Bradshaw, Robert D; Chen, Robert T; Cetron, Martin S |
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| ジャーナル名 | Vaccine |
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| 組織名 | Epidemic Intelligence Service, Epidemiology Program Office, Centers for Disease;Control and Prevention, Atlanta, GA, USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/15837230/ |
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