| アブストラクト | During 1996 through 2004, 29 cases of yellow fever vaccine-associated viscerotropic disease (YEL-AVD) have been reported worldwide; 17 were fatal. Stress-dose corticosteroid (SDS) therapy has recently been found to improve survival among patients with septic shock but benefit for the treatment of YEL-AVD patients in septic shock is unknown. We retrospectively reviewed medical records of 11 U.S. YEL-AVD cases reported to the Vaccine Adverse Event Reporting System (VAERS) from 1996 through 2004. Four of 11 case-patients received SDS; 3 of these 4 (75%) survived. Seven patients did not receive SDS and 2 (29%) survived. Altered mental status was documented on admission for 5 of the 11 patients; 4 of these 5 did not receive SDS and died, whereas one received SDS and survived. The use of stress-dose steroids might be a factor that influenced the survival of these YEL-AVD patients and should be further evaluated in the management of both YEL-AVD and wild-type yellow fever septic shock. |
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| 投稿日 | 2006/08/10 |
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| 投稿者 | Vellozzi, Claudia; Mitchell, Tarissa; Miller, Elaine; Casey, Christine G; Eidex, Rachel Barwick; Hayes, Edward B |
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| ジャーナル名 | The American journal of tropical medicine and hygiene |
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| 組織名 | National Immunization Program, Centers for Disease Control and Prevention,;Atlanta, Georgia 30333, USA. cvellozzi@cdc.gov |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/16896144/ |
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