| アブストラクト | BACKGROUND AND PURPOSE: Although there is no overall association between statin use and intracerebral hemorrhage (ICH), whether there is an increased risk among those with a history of ischemic stroke (IS) or transient ischemic attack (TIA) remains controversial. We evaluated the relationship of preadmission statin use with the risk of ICH in patients with a history of IS or TIA in a population-based cohort. METHODS: The Health Improvement Network primary care database in the United Kingdom was used to identify new users of low-dose aspirin and a matched comparison. Both cohorts were followed to identify incident cases of ICH, with validation by manual review of patient records and linkage to hospitalization data. In a nested case-control study, we compared the adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for ICH based on statin use in the subgroup of individuals with history of IS/TIA. RESULTS: Last statin use within 1 year of ICH (OR, 0.92; 95% CI [confidence interval], 0.60-1.4), last use between 8 days and 1 year (OR, 1.81; 95% CI, 0.99-3.28), and statin use at the time of ICH (OR, 0.77; 95% CI, 0.49-1.21) were not associated with the overall ICH risk among 157 patients with ICH and 884 controls with a history of IS/TIA. There was also no difference in 30-day rates of fatal (OR, 0.82; 95% CI, 0.41-1.64) or nonfatal (OR, 0.90; 95% CI, 0.51-1.57) ICH. CONCLUSIONS: Statin use was not associated with an increased risk of ICH among patients with a previous history of IS/TIA. |
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| ジャーナル名 | Stroke |
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| Pubmed追加日 | 2017/10/27 |
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| 投稿者 | Gaist, David; Goldstein, Larry B; Cea Soriano, Lucia; Garcia Rodriguez, Luis Alberto |
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| 組織名 | From the Department of Neurology, Odense University Hospital, Denmark (D.G.);;Department of Clinical Research, Faculty of Health Sciences, University of;Southern Denmark, Odense (D.G.); Department of Neurology and Kentucky;Neuroscience Institute, University of Kentucky, Lexington (L.B.G.); Spanish;Centre for Pharmacoepidemiologic Research (CEIFE), Madrid (L.C.S., L.A.G.R.); and;Department of Preventive Medicine and Public Health, Faculty of Medicine,;Complutense University of Madrid, Spain (L.C.S.). dgaist@health.sdu.dk.;Complutense University of Madrid, Spain (L.C.S.). |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/29070714/ |
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