| アブストラクト | OBJECTIVE: To investigate whether the risk of incident cardiovascular disease (CVD) is increased in patients with prolactinoma. DESIGN: Population-based, retrospective, open-cohort study using The Health Improvement Network (THIN) database. PATIENTS: A total of 2233 patients with prolactinoma and 10 355 matched controls (1:5 ratio) from UK General Practices contributing to THIN were included. Sex, age, body mass index and smoking status were used as matching parameters. The primary outcome was any incident CVD, defined by Read codes suggesting myocardial infarction, angina pectoris, stroke, transient ischaemic attack or heart failure. Sex-specific-adjusted incidence rate ratios (aIRRs) were calculated with Poisson regression, using clinically relevant parameters as model covariates. Sensitivity analyses were performed to check whether a change in the initial assumptions could have an impact on the findings. RESULTS: During the 6-year observation period, the composite CVD outcome was recorded in 54 patients with prolactinoma and 180 "nonexposed" individuals. The incidence rate was 1.8 and 14.8 per 1000 person-years for the females and males with prolactinoma, respectively. The aIRRs for CVD were estimated at 0.99 [95% confidence interval (CI): 0.61-1.61, P = .968)] in female patients and 1.94 (95% CI: 1.29-2.91, P = .001) in male patients. These findings remained robust in sensitivity analyses restricting to patients with documented record of dopamine agonist treatment and those with newly diagnosed prolactinoma. CONCLUSIONS: In contrast to females, men with prolactinoma have increased risk for incident CVD; the aetiology of this gender-specific finding remains to be elucidated. |
|---|
| ジャーナル名 | Clinical endocrinology |
|---|
| Pubmed追加日 | 2017/10/19 |
|---|
| 投稿者 | Toulis, Konstantinos A; Robbins, Tim; Reddy, Narendra; Balachandran, Kumarendran; Gokhale, Krishna; Wijesinghe, Haren; Cheng, Kar Keung; Karavitaki, Niki; Wass, John; Nirantharakumar, Krishnarajah |
|---|
| 組織名 | Institute of Applied Health Research, University of Birmingham, Birmingham, UK.;Department of Endocrinology, General Military Hospital, Thessaloniki, Greece.;University Hospitals Coventry and Warwickshire, Coventry, UK.;Warwick Medical School, University of Warwick, Warwick, UK.;University Hospitals of Leicester, Leicester, UK.;Institute of Metabolism and Systems Research, College of Medical and Dental;Sciences, University of Birmingham, Birmingham, UK.;Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners,;Birmingham, UK.;Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford,;Oxford, UK. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/29044586/ |
|---|
