| アブストラクト | AIMS/HYPOTHESIS: The aim of this research was to explore the relationship between incident epilepsy and type 1 diabetes in British participants. METHODS: Using The Health Improvement Network database, we conducted a retrospective, open-cohort study. Patients who were newly diagnosed with type 1 diabetes mellitus at the age of </=40 years were identified and followed-up from 1 January 1990 to 15 September 2015. These patients, identified as not suffering from epilepsy at the time of diagnosis, were randomly matched with up to four individuals without type 1 diabetes mellitus, based on age, sex and participating general practice. A Cox regression analysis was subsequently performed using Townsend deprivation index, cerebral palsy, head injury and learning disabilities as model covariates. RESULTS: The study population consisted of a total of 24,610 individuals (4922 with type 1 diabetes and 19,688 controls). These individuals were followed up for a mean of 5.4 years (approximately 132,000 person-years of follow up). Patients with type 1 diabetes were significantly more likely to be diagnosed with epilepsy during the observation period compared with controls (crude HR [95% CI]: 3.02 [1.95, 4.69]). The incidence rate was estimated to be 132 and 44 per 100,000 person-years in patients and controls, respectively. This finding persisted after adjusting for model covariates (adjusted HR [95% CI]: 3.01 [1.93, 4.68]) and was also robust to sensitivity analysis, excluding adult-onset type 1 diabetes mellitus. CONCLUSIONS/INTERPRETATION: Patients with type 1 diabetes are at approximately three-times greater risk of developing epilepsy compared with matched controls without type 1 diabetes. This should be considered when investigating seizure-related disorders in patients with type 1 diabetes mellitus. |
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| ジャーナル名 | Diabetologia |
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| Pubmed追加日 | 2016/11/1 |
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| 投稿者 | Dafoulas, George E; Toulis, Konstantinos A; Mccorry, Dougall; Kumarendran, Balachadran; Thomas, G Neil; Willis, Brian H; Gokhale, Krishna; Gkoutos, George; Narendran, Parth; Nirantharakumar, Krishnarajah |
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| 組織名 | Institute of Applied Health Research, University of Birmingham, Birmingham, UK.;First Department of Propaedeutic Internal Medicine, Diabetes Center, National and;Kapodistrian University of Athens Medical School, Athens, Greece.;Department of Endocrinology, 424 General Army Training Hospital, Thessaloniki,;Greece.;Department of Neuroscience, University Hospitals Birmingham NHS Foundation Trust,;Birmingham, UK.;Centre for Computational Biology, University of Birmingham, Birmingham, UK.;Centre for Endocrinology, Diabetes and Metabolism, Institute of Metabolism and;Systems Research, University of Birmingham, Room 229, Medical School, College of;Medical and Dental Sciences, Edgbaston, Birmingham, B15 2TT, UK.;p.narendran@bham.ac.uk.;University of Birmingham, Birmingham, UK. p.narendran@bham.ac.uk.;University of Birmingham, Birmingham, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/27796422/ |
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