| アブストラクト | BACKGROUND: To describe patterns of antibiotic outpatient use in 3 European countries, including 2 new pediatric-specific quality indicators (QIs). METHODS: A cohort study was conducted, 2001-2010, using electronic primary care records of 2,196,312 children up to 14 (Pedianet, Italy) or 18 years (The Health Improvement Network, United Kingdom; Integrated Primary Care Information database, The Netherlands) contributing 12,079,620 person-years. Prevalence rates of antibiotic prescribing per year were calculated and antibiotics accounting (drug utilization) for 90% of all antibiotic prescriptions were identified (drug utilization 90% method). The ratio between users of broad to narrow-spectrum penicillins, cephalosporins and macrolides (B/N ratio) and 2 pediatric-specific QIs: the proportion of amoxicillin users (amoxicillin index) and the ratio between users of amoxicillin to broad-spectrum penicillins, cephalosporins and macrolides (A/B ratio) were determined. RESULTS: The overall annual prevalence of antibiotic prescriptions was 18.0% in the Netherlands, 36.2% in the United Kingdom and 52.0% in Italy. Use was maximal in the first years of life. The number of antibiotics accounting for the drug utilization 90% was comparable. The B/N ratio varied widely from 0.3 to 74.7. The amoxicillin index was highest in the Netherlands and the United Kingdom (50-60%), lowest in Italy (30%) and worsened over time in the United Kingdom and Italy. The A/B ratio in 2010 was 0.3 in Italy, 1.7 in the Netherlands and 5.4 in the United Kingdom. CONCLUSIONS: The patterns of antibiotic prescribing varied highly with age and country. The pediatric-specific QIs combined with the total prevalence rate of use provide a clear picture of the trends of community childhood antibiotic prescribing, allowing monitoring of the impact of policy interventions. |
|---|
| ジャーナル名 | The Pediatric infectious disease journal |
|---|
| Pubmed追加日 | 2016/9/15 |
|---|
| 投稿者 | de Bie, Sandra; Kaguelidou, Florentia; Verhamme, Katia M C; De Ridder, Maria; Picelli, Gino; Straus, Sabine M J M; Giaquinto, Carlo; Stricker, Bruno H; Bielicki, Julia; Sharland, Mike; Sturkenboom, Miriam C J M |
|---|
| 組織名 | From the *Department of Medical Informatics, Erasmus University Medical Center,;Rotterdam, The Netherlands; daggerDepartment of Pediatric Pharmacology and;Pharmacogenetics, Hopital Robert Debre, APHP; Univ Paris 7-Diderot, Sorbonne;Paris Cite, EA08; INSERM CIC1426, Paris, France; double daggerInternational;Pharmaco-epidemiology and Pharmaco-economics Research Center, Desio, Italy;;section signMedicines Evaluations Board, Utrecht, The Netherlands; paragraph;signSocieta Italiana di Medicina Generale, Florence, Italy; ||Department of;Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; and;**Paediatric Infectious Diseases Research Group, St George's University London,;London, United Kingdom. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/27626915/ |
|---|
