| アブストラクト | OBJECTIVES: To estimate the incidence and prevalence of SLE in Italy, and to describe the demographic and clinical characteristics of patients with newly diagnosed SLE. METHODS: A retrospective cohort study was conducted using The Health Improvement Network general practice database in Italy, encompassing data from 634 753 people. SLE cases were identified over the period 2017-2022, employing three alternative definitions to provide a more detailed understanding of SLE characteristics. Incidence rates were expressed as cases per 100 000 person-years and prevalence as cases per 100 000 people. Demographic and clinical characteristics of incident SLE cases were also studied. RESULTS: From 2017 to 2022, a total of 191 incident and 1385 prevalent cases were identified under our first definition. In 2022, the incidence rate was 6.51 cases (95% CI 6.29 to 6.74) per 100 000 person-years, and the prevalence 60.57 (95% CI 59.89 to 61.25) per 100 000 people, being the prevalence five times higher in women compared with men. Both estimates have trended upwards since 2017. A geographical variation across the country was also seen. The demographic and clinical characteristics of incident SLE cases were described, while the potential associations of SLE incidence with some pre-existing conditions were observed, such as chronic kidney disease, chronic hepatic disease, rheumatoid arthritis and Sjogren's syndrome. CONCLUSIONS: The results of this nationwide study, the first conducted in Italy, showed that the incidence of SLE has increased in Italy in recent years. Age, sex, and area of residence strongly correlate with the epidemiology of this condition. |
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| ジャーナル名 | Lupus science & medicine |
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| Pubmed追加日 | 2024/5/15 |
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| 投稿者 | Ferrara, Pietro; Antonazzo, Ippazio C; Zamparini, Manuel; Fornari, Carla; Borrelli, Cristiana; Boarino, Silvia; Bettiol, Alessandra; Mattioli, Irene; Palladino, Pasquale; Zanzottera Ferrari, Elena; Emmi, Giacomo; Mantovani, Lorenzo G; Mazzaglia, Giampiero |
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| 組織名 | Center for Public Health Research, University of Milan-Bicocca, Monza, Italy.;Laboratory of Public Health, Istituto Auxologico Italiano Istituto di Ricovero e;Cura a Carattere Scientifico, Milano, Italy.;Center for Public Health Research, University of Milan-Bicocca, Monza, Italy;m.zamparini1@campus.unimib.it.;Medical Affairs Department, AstraZeneca, Milan, Italy.;Department of Experimental and Clinical Medicine, University of Florence,;Firenze, Italy.;Cegedim Health Data, Milan, Italy.;Department of Medicine - Centre for Inflammatory Diseases, Monash University,;Clayton, Victoria, Australia. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38744457/ |
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