| アブストラクト | BACKGROUND: Budesonide/glycopyrronium bromide/formoterol fumarate (BUD/GLY/FOR) single inhaler triple therapy became available to prescribe to patients with severe chronic obstructive pulmonary disease (COPD) in France in 2021. The characteristics of patients prescribed BUD/GLY/FOR triple therapy and guideline adherence have not been previously described in France. OBJECTIVE: To describe the characteristics of COPD patients initiated on BUD/GLY/FOR triple therapy, assess adherence to COPD management guidelines, and explore any differences by prescribing physician. MATERIALS AND METHODS: A cross-sectional study using data from The Health Improvement Network (THIN((R))) France database was conducted. Patients with >/=2 recorded diagnostic codes for COPD were included. Demographic characteristics, comorbidities, management, COPD-related characteristics, and guideline adherence (Societe de Pneumologie de Langue Francaise (SPLF); Haute Autorite de Sante (HAS)), stratified by initiating physician speciality (general practitioner (GP) or pulmonologist) were described. RESULTS: A total of 263 patients initiating BUD/GLY/FOR triple therapy were included. Mean (SD) age was 68.8 (11.8) years; 53.6% were male. Mean (SD) COPD duration was 6.4 (5.5) years. Comorbidities were common, with slightly more cardiometabolic and mental health conditions recorded in the GP-initiated group, and more comorbid respiratory conditions recorded in the pulmonologist-initiated group. About 77.2% (n=203) of patients had at least one moderate or severe exacerbation in the 12 months before initiation. About 86.3% had a previous record of dual (n=117, 44.5%) or triple (n=110, 41.8%) therapy. About 68.8% had been initiated on BUD/GLY/FOR triple therapy in line with SPLF guidelines (62.4% and 72.4% in the GP- and pulmonologist-initiated groups, respectively); among those with a record of COPD severity, 75.2% were initiated in line with HAS guidelines (69.2% and 76.3% in the GP- and pulmonologist-initiated groups, respectively). CONCLUSION: The majority of COPD patients are prescribed BUD/GLY/FOR triple therapy in accordance with current treatment guidelines, irrespective of whether the therapy is prescribed by a general practitioner or a pulmonologist. |
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| ジャーナル名 | International journal of chronic obstructive pulmonary disease |
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| Pubmed追加日 | 2025/4/23 |
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| 投稿者 | Deslee, Gaetan; Fabry-Vendrand, Caroline; Salmi, Elsa; Poccardi, Nolwenn; Coriat, Adrien; Ghout, Idir; Eteve-Pitsaer, Caroline; Adderley, Nicola J; Leleu, Henri |
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| 組織名 | Service de Pneumologie, INSERM UMRS-1250, Centre Hospitalier Universitaire de;Reims, Universite Reims, Champagne-Ardenne, France.;AstraZeneca, Courbevoie, France.;Cegedim Group, Boulogne-Billancourt, France.;Department of Applied Health Sciences, University of Birmingham, Edgbaston,;Birmingham, UK.;Public Health Expertise, Paris, Ile-de-France, France. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40264969/ |
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