| アブストラクト | BACKGROUND: The role COVID-19 vaccination on healthcare resource utilization (HCRU) and cost remains unclear, especially during Omicron predominance and among high risk UK populations. RESEARCH DESIGN AND METHODS: A retrospective cohort study using UK The Health Improvement Network (THIN) primary care data included adults (>/=18 years) with confirmed or suspected COVID-19 between September 2022 and May 2023. Three cohorts were defined: Highest risk (eligible for two seasonal doses), High Risk (eligible for one dose), and All COVID-19 patients. Long COVID was identified as >/=1 symptom or diagnostic/referral code, >/=4 weeks post COVID-19 diagnosis. Inverse probability of treatment weighting assessed associations between vaccination status (yes/no and time since vaccination) and long COVID, HCRU, and costs. RESULTS: In both Risk Cohorts, COVID-19 vaccination was not associated with long COVID incidence. However, in the High Risk (n = 1,889) and All Patients cohorts (n = 8,507) outpatient specialist referrals were significantly lower in the 3-6-month post-vaccination group versus > 6 months (rate ratio: 0.28; 95% CI: 0.10-0.79, p < 0.05 and 0.46; 95% CI: 0.27-0.79; p </= 0.01, respectively). CONCLUSIONS: COVID-19 vaccination was not consistently associated with incidence of long COVID or all-cause HCRU. Findings suggest potential subgroup-specific benefits, highlighting the importance of annual vaccination. Further research with larger sample size and longer-term follow-up is warranted. |
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| ジャーナル名 | Expert review of vaccines |
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| Pubmed追加日 | 2025/11/13 |
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| 投稿者 | Rai, Kiran K; Gowman, Hannah; Harrison, Cale S; Gruben, David C; Butfield, Rebecca; Hulme, Rosie; Volkman, Hannah R; Nguyen, Jennifer L; Yang, Jingyan |
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| 組織名 | Real World Evidence, Adelphi Real World, Bollington, UK.;Health & Value, Pfizer Ltd, Tadworth, UK.;Biostatistics, Pfizer Inc., Groton, CT, USA.;Global Access & Value, Pfizer Inc., New York, NY, USA.;Institute for Social and Economic Research and Policy, Columbia University, New;York, NY, USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41231115/ |
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