論文・技術情報追加のお知らせ

1. Drug-associated pancreatic cancer: insights from real-world pharmacovigilance and network pharmacology.

膵臓癌と薬剤の関連解析、早期発見が重要

対象DB：FAERS

2. Increased Risk of Retinal Vasculitis May Be Associated with Aflibercept 8 mg: A Pharmacovigilance Analysis of the FAERS Database.

抗VEGF薬による網膜血管炎のリスク

対象DB：FAERS

3. Exploring the potential association between stimulant or atomoxetine use and suicidal or self-injurious behaviors in children with attention deficit hyperactivity disorder: real-world insights from the FAERS database.

ADHD治療薬と自殺・自傷行動の関連

対象DB：FAERS

4. Pharmacovigilance analysis of immune checkpoint inhibitor-related reproductive adverse effects based on the FDA adverse event reporting system.

免疫チェックポイント阻害薬の生殖系への影響

対象DB：FAERS

5. Post-marketing safety evaluation of Vortioxetine: A decade-long pharmacovigilance study based on the FAERS database.

ボルチオキセチン使用に伴う副作用の解析

対象DB：FAERS

6. Association between GLP-1 RAs and DPP-4 inhibitors with biliary disorders: pharmacovigilance analysis.

Incretin-based療法における胆道障害リスクを分析

対象DB：FAERS

7. A disproportionality analysis of real-world events from the FDA Adverse Event Reporting System (FAERS) for Atezolizumab.

アテゾリズマブ使用に伴う副作用の解析

対象DB：FAERS

8. Post-marketing safety monitoring of Tirzepatide: a pharmacovigilance study based on the FAERS database.

ティルゼパチド使用に関する副作用の分析

対象DB：FAERS

9. Gastrointestinal toxicity of antibody-drug conjugates: a pharmacovigilance study using the FAERS database.

ADC薬剤に関連する消化器系副作用のリスクを分析

対象DB：FAERS

10. Analysis of nationwide adverse event reports on Isoniazid and Rifampin in tuberculosis prevention and treatment in South Korea.

南韓におけるLTBI治療でリファンピンの副作用を調査

対象DB：FAERS,KAERS

11. A post-marketing disproportionality analysis of the safety of ribociclib based on the FDA Adverse Event Reporting System.

リボシクリブの実臨床における安全性をFAERSデータで評価

対象DB：FAERS

12. Large Hemorrhagic Pericardial Effusion and Cardiac Tamponade Following BNT162b2 (BioNTech/Pfizer) Vaccine.

mRNAワクチン接種後に心タンポナーデが発生した症例

対象DB：FAERS,VAERS

13. Distal middle cerebral artery aneurysms: What non-neurosurgeons need to know.

遠位中大脳動脈瘤：非神経外科医が知るべきこと

対象DB：JADER

14. Influence of rapidly increased numbers of reports on adverse events of the COVID-19 vaccine in the Japanese pharmacovigilance database on disproportionality analysis of antineoplastic drug-associated adverse cardiovascular events.

COVID-19ワクチン報告が抗癌剤の副作用シグナルに影響

対象DB：JADER

15. Targeted liquid biopsy for brain tumors.

CSFは脳腫瘍の液体生検におけるバイオマーカー源として有望

対象DB：JADER

16. Network analysis of adverse event patterns following immunization with mRNA COVID-19 vaccines: real-world data from the European pharmacovigilance database EudraVigilance.

mRNA COVID-19ワクチンの副作用分析、継続的監視が重要

対象DB：EudraVigilance

17. Hypertension associated with serotonin reuptake inhibitors: A new analysis in the WHO pharmacovigilance database and examination of dose-dependency.

抗うつ薬(SRI)使用と高血圧報告に関連

対象DB：VigiBase

18. Association between antidepressant drugs and falls in older adults: A mediation analysis in the World Health Organization's pharmacovigilance database.

抗うつ薬は高齢者の転倒リスクに関連

対象DB：VigiBase

19. Comparative retrospective study on surgical outcomes of hand-sewn anastomosis versus stapling anastomosis for colectomy using a nationwide inpatient database in Japan with propensity score matching.

SAは最近、より一般的になり、HA群では再手術リスクが高いが、SA群では内視鏡止血リスクが高い

対象DB：DPC

20. U-shaped relationship between body mass index and intracerebral hemorrhage-related functional decline.

ICH後の機能低下リスクはBMI 22.2-30.4で低い

対象DB：DPC

21. In-hospital mortality of heat-related disease associated with wet bulb globe temperature: a Japanese nationwide inpatient data analysis.

低WBGT地域で熱中症患者の院内死亡率が高い

対象DB：DPC

22. Contemporary Use of Oral Inotropes in the Outpatient Treatment of Heart Failure: Analysis of a Japanese Nationwide Database.

経口強心薬の使用は予後改善に寄与せず

対象DB：NDB

23. Addressing uncertainty in identifying pregnancies in the English CPRD GOLD Pregnancy Register: a methodological study using a worked example.

CPRD妊娠データの精度向上手法を提案

対象DB：CPRD

24. Missed opportunities to manage complex comorbidity of heart failure, type 2 diabetes mellitus and chronic kidney disease: a retrospective cohort study.

HF、CKD、T2Dの併存患者でガイドライン遵守が不十分

対象DB：CPRD

25. Health conditions in adults with atrial fibrillation compared with the general population: a population-based cross-sectional analysis.

AF患者は心血管疾患以外の併存疾患も多い

対象DB：CPRD

26. Cardiovascular disease morbidity is associated with social deprivation in subjects with familial hypercholesterolaemia (FH): A retrospective cohort study of individuals with FH in UK primary care and the UK Simon Broome register, linked with national hospital records.

低所得層のFH患者はCVDリスクが高い

対象DB：CPRD

27. Effect of intra-articular corticosteroid injections for osteoarthritis on the subsequent use of pain medications: a UK CPRD cohort study.

IACIはKOAやHOA患者の鎮痛薬使用を減少

対象DB：CPRD

28. Patterns of analgesic utilisation among people with knee osteoarthritis: a cohort study using UK primary care data.

KOA患者の鎮痛薬持続使用率を分析

対象DB：CPRD

29. An interpretable machine learning approach for detecting psoriatic arthritis in a UK primary care psoriasis cohort using electronic health records from the Clinical Practice Research Datalink.

乾癬患者のPsA発症予測に機械学習を活用

対象DB：CPRD