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論文・技術情報追加のお知らせ

• 論文・技術情報追加のお知らせ

  2025年11月30日～2025年12月6日の間に収集した論文情報を追加しました。

  1. Postmarketing pharmacovigilance study of levothyroxine based on FDA adverse event reporting system (FAERS) and Mendelian randomization.

  レボチロキシンで未記載の有害事象と因果性を確認

  対象DB：FAERS

  2. Drug exposure before and during pregnancy and thromboembolic events: a disproportionality analysis from the FAERS database.

  妊娠関連血栓塞栓症は特定薬剤でリスク増大

  対象DB：FAERS

  3. Adverse reactions of PD-1/PD-L1 inhibitors in cancer: FEARS database analysis and protocols to mitigate immune-related events in elderly patients and when using pembrolizumab and atezolizumab.

  PD-1/PD-L1阻害薬の重篤ADRは高齢男性で多い

  対象DB：FAERS

  4. Graves' orbitopathy following Alemtuzumab treatment for multiple sclerosis: a systematic review and real-world insights.

  アレムツズマブ後の眼症状GOが過小認識されている

  対象DB：FAERS

  5. Signal identification of adverse reactions related to phentermine/topiramate: A study based on FAERS reports.

  フェンテルミン/トピラマートで多様な新規有害事象を検出

  対象DB：FAERS

  6. Signal mining of botulinum toxin type A adverse events based on FAERS database and its implications for the treatment of cerebral palsy.

  ボツリヌスA毒のCP治療で多様な有害事象シグナル確認

  対象DB：FAERS

  7. Risk Signals of Antibody-Drug Conjugates in Bladder Cancer: A Real-World FAERS Study.

  膀胱癌ADCで薬剤別に異なる安全性シグナルを確認

  対象DB：FAERS

  8. A real-world safety analysis of infection-related adverse events associated with belimumab, rituximab, and TNF inhibitors using the FAERS database.

  生物学的製剤でPMLやTBなど感染リスクに差

  対象DB：FAERS

  9. Severe cutaneous adverse reactions linked to medications in children and adolescents: a pharmacovigilance study based on the FDA Adverse Event Reporting System database.

  小児の重篤皮膚障害は抗てんかん薬等で多く早期発症

  対象DB：FAERS

  10. Evolving Trends and Drug Class Dynamics in Drug-Induced Myocarditis: A 2-Decade Comparative Analysis of Pharmacovigilance Data.

  薬剤性心筋炎が増加し抗体薬と抗精神病薬が高リスク

  対象DB：FAERS,JADER

  11. Safety profile of TNF- alpha Inhibitors in pediatric patients: A post-marketing surveillance study based on the FAERS database.

  小児TNF阻害薬で多系統AEと感染リスク増大

  対象DB：FAERS

  12. Risk of autoimmune disease flares after recombinant zoster vaccine: A vaccine safety analysis based on the Vaccine Adverse Event Reporting System database.

  RZVで自己免疫疾患の増悪リスク上昇

  対象DB：FAERS,VAERS

  13. Drug-induced immune-mediated uveitis: a real-world pharmacovigilance analysis using FAERS and JADER databases.

  多薬剤でIMUリスク増大、特に眼科薬が顕著

  対象DB：FAERS,JADER

  14. Ceritinib-ibuprofen synergistic hepatotoxicity: Insights from real-world data and liver organoid models.

  セリチニブ併用でDILI増強、特にイブ併用

  対象DB：FAERS

  15. Beyond the common ground: Unmasking unique toxicity signatures of cisplatin, docetaxel, and fluorouracil with implications for head and neck cancer treatment.

  TPF3薬で明確な毒性差を示す安全性解析

  対象DB：EudraVigilance

  16. Peripheral Neuropathy Associated With Proteasome Inhibitors and Immunomodulatory Drugs: A Pharmacovigilance Disproportionality Analysis Using VigiBase.

  IMiDs/PIは各種末梢神経障害と有意関連

  対象DB：VigiBase

  17. Relationship between volatile anesthetics and functional outcomes in patients with subarachnoid hemorrhage.

  揮発性麻酔薬はSAH転帰を改善せず

  対象DB：DPC

  18. Machine Learning-Based Prediction of In-Hospital Falls in Adult Inpatients: Retrospective Observational Multicenter Study.

  機械学習で院内転倒を高精度に予測可能

  対象DB：DPC

  19. Clinical characteristics and outcomes of acute eosinophilic pneumonia: A nationwide descriptive study.

  AEPは予後良好だが低酸素例は治療強化を要す

  対象DB：DPC

  20. Clinical characteristics and outcomes of cardiovascular surgery and transcatheter procedures in adults with Down syndrome and congenital heart disease.

  ダウン症CHD成人は手術で死亡例あり、カテ治療は良好

  対象DB：DPC

  21. Incidence of Hepatobiliary Injury in Patients Undergoing Dai-kenchu-to Administration Following Gastrectomy: A Retrospective Cohort Study Using Japanese Diagnosis Procedure Combination Data.

  大建中湯は胃切除後の肝胆障害リスクを増やさず安全

  対象DB：DPC

  22. Predictors of and hospital-level variation in intensive care unit readmissions in Japan: a nationwide inpatient database study.

  日本のICU早期再入室は稀で、退室時重症度が鍵

  対象DB：DPC

  23. Real-World Treatment Patterns in Patients with Metastatic Castration-Sensitive Prostate Cancer in Japan: A Retrospective Health Administrative Data Analysis.

  mCSPCでARSI使用増、ARSI併用は治療継続が最長

  対象DB：MDV

  24. Influenza Immunization at Midlife and the Risk of Parkinson Disease.

  中年期のインフル接種でPD予防効果は総体で認めず

  対象DB：CPRD

  25. Do the pharmacokinetics of statins explain psychiatric symptom improvement from adjunctive statin prescribing in severe mental illness? Three target trial emulation studies.

  スタチン併用でSMI改善は限定的、特定併用に僅かな効果

  対象DB：CPRD

  26. Evaluating XAI techniques under class imbalance using CPRD data.

  医療XAIはクラス不均衡で説明一貫性が大きく揺らぐことを実証

  対象DB：CPRD

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