| アブストラクト | BACKGROUND: Bullous pemphigoid is associated with poorly understood dramatically increased early mortality rates. OBJECTIVES: To assess the incidence of acute events predisposing to early mortality. METHODS: Computerized medical records from the Health Improvement Network, a large population-based U.K. general practice database, were used to conduct a cohort analysis. Outcome measures were incidence rates of myocardial infarction, pulmonary embolism, pneumonia and sepsis compared with a matched control population. RESULTS: People with bullous pemphigoid were three times as likely to develop pneumonia, adjusted rate ratio 2.94 [95% confidence interval (CI) 2.01-4.31] or pulmonary embolism, adjusted rate ratio 3.12 (95% CI 1.37-7.12) compared with matched controls. No statistically significant increase was seen for myocardial infarction, adjusted rate ratio 1.24 (95% CI 0.66-2.33), or sepsis, adjusted rate ratio 2.02 (95% CI 0.78-5.21). CONCLUSIONS: The risk of pulmonary embolism and pneumonia is increased following a diagnosis of bullous pemphigoid. It may be possible to reduce associated mortality through considering prophylaxis with either antithromboembolic measures or antibiotic therapy and vaccination. |
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| ジャーナル名 | The British journal of dermatology |
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| 投稿日 | 2009/08/18 |
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| 投稿者 | Langan, S M; Hubbard, R; Fleming, K; West, J |
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| 組織名 | Centre of Evidence-based Dermatology, University of Nottingham, Queen's Medical;Centre, Nottingham, UK. sinead.langan@nottingham.ac.uk |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/19681857/ |
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