BACKGROUND: Chronic inflammatory conditions have been linked to dementia, but little is known about the role of atopic eczema, an inflammatory condition recently recognized to be common among older adults.
OBJECTIVE: To determine whether active atopic eczema is associated with incident dementia.
METHODS: A longitudinal cohort study of 1,767,667 individuals aged 60 to 99 years registered with The Health Improvement Network, a primary care cohort in the United Kingdom. The diagnoses of atopic eczema and dementia were identified using medical record codes.
RESULTS: The incidence of dementia was 57 per 10,000 person-years among those with atopic eczema during follow-up (12.1% of the population) compared with 44 per 10,000 person-years in the control group. This translated to a 27% increased risk of dementia (hazard ratio, 1.27; 95% CI, 1.23-1.30) in adjusted Cox proportional hazard models. Similar associations were observed in subgroup analyses of vascular dementia and Alzheimer's disease. The association persisted after additionally adjusting for the use of systemic corticosteroids (hazard ratio, 1.29; 95% CI, 1.26-1.33) and potential mediators (hazard ratio, 1.19; 95% CI, 1.16-1.22). More severe eczema was associated with a higher risk of dementia.
LIMITATIONS: Lack of detailed data on severity.
CONCLUSION: Atopic eczema was associated with a small but increased risk of incident dementia. The association increased with the severity of atopic eczema.
|投稿者||Magyari, Alexa; Ye, Morgan; Margolis, David J; McCulloch, Charles E; Cummings, Steven R; Yaffe, Kristine; Langan, Sinead M; Abuabara, Katrina|
|組織名||UC Berkeley School of Public Health, Berkeley, California.;Department of Dermatology, University of California, San Francisco School of;Medicine (UCSF), San Francisco, California.;Department of Dermatology and Center for Epidemiology and Biostatistics,;University of Pennsylvania, Perelman School of Medicine, Philadelphia,;Pennsylvania.;Division of Biostatistics, University of California, San Francisco School of;San Francisco Coordinating Center, California Pacific Medical Center Research;Institute, San Francisco, California; Department of Epidemiology and;Biostatistics, University of California, San Francisco, San Francisco,;California.;Center for Population Brain Health, University of California, San Francisco;School of Medicine (UCSF), San Francisco, California.;Faculty of Epidemiology and Population Health, London School of Hygiene and;Tropical Medicine, Keppel Street, London, United Kingdom.;UC Berkeley School of Public Health, Berkeley, California; Department of;Dermatology, University of California, San Francisco School of Medicine (UCSF),;San Francisco, California. Electronic address: firstname.lastname@example.org.|