| アブストラクト | OBJECTIVE: Increasing psoriasis severity has been associated with comorbidities including cardiovascular disease. The objective of this study was to examine the association of psoriasis severity with the development of PsA. METHODS: A prospective population-based cohort study was performed within The Health Improvement Network, a UK medical record database. Patients aged 25-60 years with a code for psoriasis were randomly selected between 2008 and 2011. Questionnaires were sent to their general practitioners to confirm the diagnosis of psoriasis and provide the patient's approximate body surface area (BSA). Incidence of PsA was calculated by BSA, and Cox proportional hazard ratios were used to examine the risk of developing PsA by BSA category after adjusting for other covariates. RESULTS: Among 10 474 questionnaires sent, 9987 (95%) were returned, 9069 (91%) had confirmed psoriasis, and BSA was provided for 8881 patients: 52% had mild psoriasis, 36% moderate psoriasis and 12% severe psoriasis. The mean age was 46, and 49% were female. Mean follow-up time was 4.2 years (s.d. 2.1); the incidence of PsA was 5.4 cases per 1000 person-years. After adjusting for age and sex, BSA >10% [hazard ratio (HR) 2.01, 95% CI: 1.29, 3.13], BSA 3-10% (HR 1.44, 95% CI: 1.02, 2.03), obesity (HR 1.64, 95% CI: 1.19, 2.26) and depression (HR 1.68, 95% CI: 1.21, 2.33) were associated with incident PsA. CONCLUSIONS: In this large prospective cohort study, BSA assessed by general practitioners was a strong predictor of developing PsA, and obesity and depression were additive risk factors. |
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| 投稿日 | 2021/9/12 |
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| 投稿者 | Ogdie, Alexis; Shin, Daniel B; Love, Thorvardur Jon; Gelfand, Joel M |
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| ジャーナル名 | Rheumatology (Oxford, England) |
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| 組織名 | Departments of Medicine/Rheumatology.;Department of Biostatistics, Epidemiology and Informatics, Perelman School of;Medicine.;Department of Dermatology, Perelman School of Medicine, University of;Pennsylvania, Philadelphia, PA, USA.;Department of Medicine, University of Iceland and Landspitali, Reykjavik,;Iceland. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/34508558/ |
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