| アブストラクト | OBJECTIVES: The epidemiology of Behcet's disease (BD) has not been well characterized in the UK. Evidence on the risk of cardiovascular disease, thromboembolic disease and mortality in patients with BD compared with the general population is scarce. METHODS: We used a large UK primary care database to investigate the epidemiology of BD. A retrospective matched cohort study was used to assess the following outcomes: risk of cardiovascular, thromboembolic disease and mortality. Controls were selected at a 1:4 ratio (age and gender matched). Cox proportional hazard models were used to derive adjusted hazard ratios (aHR). RESULTS: The prevalence of BD was 14.61 (95% CI 13.35-15.88) per 100 000 population in 2017. A total of 1281 patients with BD were compared with 5124 age- and gender-matched controls. There was significantly increased risk of ischaemic heart disease [aHR 3.09 (1.28-7.44)], venous thrombosis [aHR 4.80 (2.42-9.54)] and mortality [aHR 1.40 (1.07-1.84)] in patients with BD compared with corresponding controls. Patients with BD were at higher risk of pulmonary embolism compared with corresponding controls at baseline [adjusted odds ratio 4.64 (2.66-8.09), P < 0.0001]. The majority of patients with pulmonary embolism and a diagnosis of BD had pulmonary embolism preceding the diagnosis of BD, not after (87.5%; n = 28/32). CONCLUSION: BD has a higher prevalence than previously thought. Physicians should be aware of the increased risk of developing ischaemic heart disease, stroke/transient ischaemic attack and deep venous thrombosis in patients with BD at an earlier age compared with the general population. Risk of embolism in patients with BD might vary across the disease course. |
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| ジャーナル名 | Rheumatology (Oxford, England) |
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| 投稿日 | 2020/2/11 |
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| 投稿者 | Thomas, Tom; Chandan, Joht Singh; Subramanian, Anuradhaa; Gokhale, Krishna; Gkoutos, George; Harper, Lorraine; Buckley, Christopher; Chandratre, Priyanka; Raza, Karim; Situnayake, Deva; Nirantharakumar, Krishnarajah |
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| 組織名 | Translational Gastroenterology Unit, University of Oxford, OxfordUK.;Kennedy Institute of Rheumatology, University of Oxford, OxfordUK.;Wellcome Centre for Human Genetics, University of Oxford, OxfordUK.;Institute of Applied Health Research, University of Birmingham, BirminghamUK.;Warwick Medical School, University of Warwick, WarwickUK.;Institute of Clinical Sciences, Centre for Translational Inflammation Research,;University of Birmingham, BirminghamUK.;Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.;Birmingham National Centre of Excellence for Behcet's Disease, Sandwell and West;Hospitals Birmingham, Birmingham, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/32040196/ |
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