Impact of glycaemic control on fracture risk in 5368 people with newly diagnosed Type 1 diabetes: a time-dependent analysis.
AIMS: To assess whether glycaemic control is associated with a lifelong increased risk of fracture in people with newly diagnosed Type 1 diabetes.
METHODS: People with newly diagnosed Type 1 diabetes between 1 January 1995 and 10 May 2016 were identified in The Health Improvement Network database. Longitudinal HbA1c measurements from diagnosis to fracture or study end or loss to follow-up were collected. A Cox proportional hazards model with HbA1c included as a time-dependent variable was fitted to these data.
RESULTS: Some 5368 people with newly diagnosed Type 1 diabetes were included. The estimated adjusted hazard ratio (aHR) for HbA1c was statistically significant [aHR 1.007; 95% confidence interval (CI) 1.002-1.011 (mmol/mol) and aHR 1.07; 95% CI 1.03-1.12 (%)]. An incremental higher risk of fracture was observed with increasing levels of HbA1c .
CONCLUSIONS: In people with newly diagnosed Type 1 diabetes, higher HbA1c is associated with an increased risk for fractures.
|ジャーナル名||Diabetic medicine : a journal of the British Diabetic Association|
|投稿者||Thayakaran, R; Perrins, M; Gokhale, K M; Kumaran, S; Narendran, P; Price, M J; Nirantharakumar, K; Toulis, K A|
|組織名||Institute of Applied Health Research, University of Birmingham, Birmingham, UK.;Department of Diabetes, University Hospitals Birmingham NHS Foundation Trust,;Birmingham, UK.;Institute of Immunology and Immunotherapy, Birmingham, UK.;NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS;Foundation Trust and University of Birmingham, Birmingham, UK.;Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham,;Health Data Research UK Midlands, Birmingham, UK.|