| アブストラクト | AIMS: To assess whether glycaemic control is associated with a lifelong increased risk of fracture in people with newly diagnosed Type 1 diabetes. METHODS: People with newly diagnosed Type 1 diabetes between 1 January 1995 and 10 May 2016 were identified in The Health Improvement Network database. Longitudinal HbA(1c) measurements from diagnosis to fracture or study end or loss to follow-up were collected. A Cox proportional hazards model with HbA(1c) included as a time-dependent variable was fitted to these data. RESULTS: Some 5368 people with newly diagnosed Type 1 diabetes were included. The estimated adjusted hazard ratio (aHR) for HbA(1c) was statistically significant [aHR 1.007; 95% confidence interval (CI) 1.002-1.011 (mmol/mol) and aHR 1.07; 95% CI 1.03-1.12 (%)]. An incremental higher risk of fracture was observed with increasing levels of HbA(1c) . CONCLUSIONS: In people with newly diagnosed Type 1 diabetes, higher HbA(1c) is associated with an increased risk for fractures. |
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| ジャーナル名 | Diabetic medicine : a journal of the British Diabetic Association |
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| 投稿日 | 2019/3/9 |
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| 投稿者 | Thayakaran, R; Perrins, M; Gokhale, K M; Kumaran, S; Narendran, P; Price, M J; Nirantharakumar, K; Toulis, K A |
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| 組織名 | Institute of Applied Health Research, University of Birmingham, Birmingham, UK.;Department of Diabetes, University Hospitals Birmingham NHS Foundation Trust,;Birmingham, UK.;Institute of Immunology and Immunotherapy, Birmingham, UK.;NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS;Foundation Trust and University of Birmingham, Birmingham, UK.;Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham,;Health Data Research UK Midlands, Birmingham, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/30848519/ |
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