| アブストラクト | PURPOSE: We aimed at estimating the incidence of diabetic retinopathy (DR) and maculopathy (DMP) among newly diagnosed type 1 (t1DM) and type 2 diabetic patients (t2DM) in the United Kingdom primary care system. The incidence of DMP among patients with DR was also estimated. METHOD: We conducted a cohort study using The Health Improvement Network database. The cohort included 64,983 incident diabetic patients (97.3% were t2DM) aged 1-84 years diagnosed between 2000 and 2007. This cohort was followed from the date of diabetes diagnosis until recording of DR or DMP in two separate follow-ups. Follow-up was censored at 85 years of age, death, or end of 2008. An additional follow-up was conducted from DR to DMP diagnosis using similar censoring reasons. DR and DMP cumulative incidences were calculated as well as incidence rates (IR; cases per 1,000 person-years) per calendar period (2000-2001 and 2006-2007). RESULTS: Follow-up for DR: 9 years after diabetes diagnosis, 28% of t2DM and 24% of t1DM patients had developed DR (7,899 incident DR cases). During the first 2 years with diabetes, the IR was almost 2 times higher in patients diagnosed with diabetes in 2006-2007 (47.7) than among those diagnosed in 2000-2001 (24.5). Follow-up for DMP: 9 years after diabetes diagnosis, 3.6% of t2DM and 4.4% of t2DM patients had developed DMP (912 incident DMP cases). During the first 2 years with diabetes, the IR was three times higher in patients diagnosed with diabetes in 2006-2007 (5.8) than among those diagnosed in 2000-2001 (1.8). Macular oedema occurred in 0.8% of patients. CONCLUSIONS: In a cohort of incident diabetes, 28% of patients developed retinopathy and 4% maculopathy within the first 9 years. The 2-year IRs of DR and DMP were higher in patients diagnosed with diabetes during the period 2006-2007 than in those diagnosed during the 2000-2001 period. |
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| ジャーナル名 | PloS one |
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| 投稿日 | 2014/6/26 |
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| 投稿者 | Martin-Merino, Elisa; Fortuny, Joan; Rivero-Ferrer, Elena; Garcia-Rodriguez, Luis Alberto |
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| 組織名 | Centro Espanol de Investigacion Farmacoepidemiologica, Madrid, Spain.;DS&E - Global Clinical Epidemiology, Novartis Farmaceutica S.A., Barcelona,;Spain. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/24963628/ |
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