| アブストラクト | BACKGROUND: The hepatitis C virus (HCV) is a major cause of global morbidity and mortality, with conflicting evidence regarding a possible association with psoriasis. OBJECTIVE: To determine the prevalence of HCV in psoriasis patients, compared to controls, and to determine the incidence of hepatic decompensation in HCV+ psoriasis patients compared to HCV+ controls. METHODS: Cross-sectional and cohort studies were conducted in The Health Improvement Network (THIN). RESULTS: In fully adjusted models, a statistically significant increase in prevalence was seen in the adults with psoriasis (OR: 1.24, 95% CI 1.10-1.40). A "dose-response" of HCV prevalence with increasing psoriasis severity was not observed. HCV+ patients with psoriasis had a non-statistically significant increased incidence of hepatic decompensation compared to HCV+ individuals without psoriasis (aHR: 1.58, 95% CI: 0.90-2.77). The risk was highest and statistically significant, in those with moderate-to-severe psoriasis (aHR: 21.51, 95% CI: 7.58-61.03). CONCLUSIONS: These results demonstrate a higher prevalence of HCV in adults with psoriasis and a higher rate of hepatic decompensation in HCV+ individuals with moderate-severe psoriasis. |
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| ジャーナル名 | Journal of the European Academy of Dermatology and Venereology : JEADV |
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| Pubmed追加日 | 2017/5/10 |
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| 投稿者 | Noe, M H; Grewal, S K; Shin, D B; Ogdie, A; Takeshita, J; Gelfand, J M |
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| 組織名 | Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA.;Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania,;Philadelphia, PA, USA.;Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/28485831/ |
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