| アブストラクト | BACKGROUND: Inhaled corticosteroids (ICS) are the cornerstone of asthma therapy. The ICS-to-total-asthma-medication ratios, calculated from claims data, indicate potentially risky disease management in asthma. Our aim was to assess the utility of ICS-to-total-asthma-medication ratios from primary care electronic medical records (EMRs) in detecting patients at risk of asthma exacerbation, as approached by prescription of oral corticosteroids and/or antibiotics. METHODS: Retrospective cohort studies were identified, using the Health Improvement Network general practice database (THIN, United Kingdom) and the Cegedim Longitudinal Patient Data (France). We selected asthma patients aged 16-40 years, with >/= 4 prescriptions for asthma medications in 2007 and >/= 1 prescription in 2008. For each country, three groups were defined according to ratio value in 2008: 0% (non-ICS users), <50% (low-ICS-ratio group) and >/= 50% (high-ICS-ratio group). Outcomes were marker of asthma exacerbations: systemic corticosteroids and antibiotics. They were compared between groups in each country. RESULTS: Among 38,637 British and 4,587 French patients, higher numbers of prescriptions per patient of systemic corticosteroids, antibiotics and total asthma medications were observed in the low-ICS-ratio groups compared to other groups (p < 0.0001 for each outcome in both countries). Likewise, low-ICS-ratio patients had more medical contacts (p < 0.0001 in both countries), suggesting poorly controlled asthma. ICS-treated patients had lower risks of receiving systemic corticosteroids in 2008 in the high-ICS-ratio group, compared to the low-ICS-ratio group: RR = 0.54, 95%CI = [0.50-0.57] and RR = 0.78, 95%CI = [0.67-0.91] in the UK and France, respectively. CONCLUSIONS: Patients with high ICS-to-total-asthma-medication ratios presented fewer asthma-related outcomes. The low ICS-to-total-asthma-medication ratio calculated with EMRs data reflects insufficient prescribing of ICS relative to all asthma medications, which may lead to deteriorated asthma control. |
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| ジャーナル名 | BMC family practice |
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| Pubmed追加日 | 2015/4/17 |
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| 投稿者 | Laforest, Laurent; Licaj, Idlir; Devouassoux, Gilles; Eriksson, Irene; Caillet, Pascal; Chatte, Gerard; Belhassen, Manon; Van Ganse, Eric |
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| 組織名 | Pharmacoepidemiology Lyon, UMR 5558 CNRS - Claude Bernard University, Lyon,;France. laurent.laforest@univ-lyon1.fr.;France. idlir.licaj@gmail.com.;Respiratory Medicine, Croix Rousse University Hospital, Lyon, France.;gilles.devouassoux@chu-lyon.fr.;Centre for Pharmacoepidemiology, Department of Medicine, Karolinska Institutet,;Stockholm, Sweden. irene.eriksson@ki.se.;Epidemiology and Public Health Department, Amiens University Hospital Center,;Amiens, France. Caillet.Pascal@chu-amiens.fr.;Respiratory physician, Caluire, France. gerard.chatte@pneumologuesacaluire.fr.;France. manon.belhassen@univ-lyon1.fr.;France. eric.van-ganse@univ-lyon1.fr.;eric.van-ganse@univ-lyon1.fr. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/25880641/ |
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