| アブストラクト | OBJECTIVES: The objectives of this study were to determine the prevalence of PsA in The Health Improvement Network (THIN), a large population-based medical records database in the UK, to examine factors associated with prevalent PsA among patients with psoriasis and to describe the use of DMARDs in patients with PsA. METHODS: Two cohorts were derived from THIN to examine the prevalence of PsA in a cross-sectional study among all patients aged 18-90 years and among a subcohort of 4900 psoriasis patients aged 45-65 years. Prescription codes were used to describe therapies after the diagnosis of PsA. Associations for prevalent PsA among psoriasis patients were assessed using logistic regression analysis. RESULTS: Among 4.8 million patients in THIN between the ages of 18 and 90 years, 9045 patients had at least one medical code for PsA, giving an overall prevalence of 0.19% (95% CI 0.19%, 0.19%). Of those patients, 45.9% with PsA have been prescribed DMARDs. Among the 4064 confirmed psoriasis patients, the prevalence of PsA was 8.6% (95% CI 7.7%, 9.5%). PsA was more prevalent among patients with severe psoriasis [odds ratio (OR) 3.34; 95% CI 2.40, 4.65], obesity (OR 1.77; 95% CI 1.30, 2.41) and duration of psoriasis for >/=10 years (OR 7.42; 95% CI 3.86, 14.25) in the fully adjusted model. CONCLUSION: The prevalence of PsA in THIN is consistent with previous population-based estimates. Limitations include a definition of PsA based on a diagnostic code rather than Classification Criteria for Psoriatic Arthritis (CASPAR) criteria. Given the large population of PsA patients, THIN is an important resource for the study of PsA. |
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| ジャーナル名 | Rheumatology (Oxford, England) |
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| 投稿日 | 2012/12/12 |
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| 投稿者 | Ogdie, Alexis; Langan, Sinead; Love, Thorvardur; Haynes, Kevin; Shin, Daniel; Seminara, Nicole; Mehta, Nehal N; Troxel, Andrea; Choi, Hyon; Gelfand, Joel M |
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| 組織名 | Division of Rheumatology, Center for Clinical Epidemiology and Biostatistics,;University of Pennsylvania, 8 Penn Tower, 1 Convention Ave, Philadelphia, PA;19104, USA. alexis.ogdie@uphs.upenn.edu |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/23221331/ |
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