| アブストラクト | BACKGROUND: Recent public health efforts, including in the UK and US, have targeted decreasing unnecessary antibiotic use. In the US, prescribing for acute non-specific respiratory infections (ARIs) has decreased, but broad-spectrum antibacterial prescribing has soared. AIM: To assess recent trends in antibacterial prescribing for ARIs in the UK. DESIGN OF STUDY: Retrospective cohort. SETTING: The Health Improvement Network database. METHOD: Outpatient ARI visits from 1 January 1990 to 31 December 2004 were selected. Outcomes were antibacterial and broad-spectrum antibacterial prescriptions per thousand person-years, and the probability of receiving an antibacterial and broad-spectrum prescription conditional on an ARI visit. RESULTS: From 1990 to 2004, antibacterial prescribing rates for ARIs decreased from 55.0 to 30.3 prescriptions/1000 person-years for adults and from 124.8 to 46.3 prescriptions/1000 person-years for children (P=0.001). The probability of receiving an antibacterial prescription after an ARI visit decreased from 70.8% to 59.5% for adults and from 46.1% to 30.8% for children (P=0.003 and 0.007, respectively). Antibacterial prescribing declined faster for younger than for older adults. Broad-spectrum antibacterial prescribing rates decreased from 3.8 to 2.9 prescriptions/1000 person-years for adults and from 5.2 to 2.2 prescriptions/1000 person years for children (P=0.005 and 0.003, respectively). The probability of broad-spectrum prescribing did not demonstrate a significant linear trend for adults (P=0.16), and decreased for children (P=0.01). CONCLUSION: UK antibacterial prescribing for ARIs has declined, similar to US trends, but there was no concomitant increase in low broad-spectrum prescribing. The success of UK strategies for limiting antimicrobial use has implications for programmes in other countries. |
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| ジャーナル名 | The British journal of general practice : the journal of the Royal College of General Practitioners |
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| 投稿日 | 2009/10/22 |
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| 投稿者 | Meropol, Sharon B; Chen, Zhen; Metlay, Joshua P |
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| 組織名 | Center for Clinical Epidemiology and Biostatistics, Penn Center for Education and;Research on Therapeutics, Department of Biostatistics and Epidemiology,;University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.;meropols@mail.med.upenn.edu |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/19843412/ |
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