| アブストラクト | AIM: To identify risk factors of diabetic retinopathy (DR) among people with Type 2 diabetes mellitus in UK primary care. METHODS: A case-control study nested in a cohort of incident Type 2 diabetes identified in The Health Improvement Network database from 2000 to 2007. Cases were people with DR (N=7735) and controls were a DR-free sample (N=9395). No age restrictions were applied. Adjusted odds ratios and 95% CIs were estimated. RESULTS: 21% of DR cases were identified during the first semester after Type 2 diabetes diagnosis. After controlling for delay on the Type 2 diabetes diagnosis, the DR risk increased with the duration of diabetes. DR increased with a mean systolic BP >/=150mmHg (1.18; 1.10-1.27), high alcohol consumption (1.34; 1.11-1.61), glycated haemoglobin (>/=75 to <86: 1.14; 1.00-1.31; >/=86 to <97mmol/mol: 1.25; 1.07-1.45; >/=97mmol/mol: 1.21; 1.07-1.37), microalbuminuria (1.16; 1.06-1.27), and retinal vein occlusion (2.47; 1.67-3.66). Glaucoma and retinal arterial occlusion showed an OR of 0.71 (0.60-0.84) and 0.63 (0.40-1.01), respectively. HDL >/=1.55mmol/l (0.88; 0.80-0.98), high triglycerides (2.3-5.6mmol/l: 0.90; 0.82-0.99; >5.6mmol/l: 0.85; 0.64-1.13) or smoking (0.89; 0.81-0.97) had a slightly reduced DR risk. Users of hypoglycaemic agents had an increased DR risk. CONCLUSION: Some DR cases were identified near the diabetes diagnosis date suggesting that a delayed diabetes diagnosis is still common. Glaucoma, retinal arterial occlusion and high HDL levels were inversely associated with DR, while retinal vein occlusion, alcohol and other well-known risk factors were positively associated. |
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| ジャーナル名 | Primary care diabetes |
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| 投稿日 | 2016/2/11 |
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| 投稿者 | Martin-Merino, Elisa; Fortuny, Joan; Rivero-Ferrer, Elena; Lind, Marcus; Garcia-Rodriguez, Luis Alberto |
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| 組織名 | Centro Espanol de Investigacion Farmacoepidemiologica, Madrid, Spain. Electronic;address: elisaceife@gmail.com.;DS&E - Global Clinical Epidemiology, Novartis Farmaceutica S.A., Barcelona,;Spain.;Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; Department;of Medicine, NU-Hospital Organization, Uddevalla, Sweden.;Centro Espanol de Investigacion Farmacoepidemiologica, Madrid, Spain. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/26860550/ |
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