| アブストラクト | BACKGROUND: The aetiology of idiopathic pulmonary fibrosis remains poorly understood, but recent studies have suggested that diabetes mellitus and gastro-oesophageal reflux may be risk factors. OBJECTIVE: To test possible associations between diabetes mellitus and gastro-oesophageal reflux with idiopathic pulmonary fibrosis in the general population. METHODS: We designed a case-control study in the setting of UK general practices contributing data to The Health Improvement Network primary care database (THIN). We selected patients over 40 years of age with a first diagnosis of idiopathic pulmonary fibrosis, and up to 4 controls per case matched by age, gender, and general practice. We estimated odds ratios for exposure to gastro-oesophageal reflux, gout, hypercholesterolaemia and diabetes mellitus using conditional logistic regression. We explored the role of confounding by smoking habit, socio-economic status, and medication with prednisolone. RESULTS: Amongst our 920 cases we found increased risks of use of insulin (odds ratio (OR) 2.36; 95% confidence interval (CI) 1.46-3.83) and use of ulcer drugs (OR 2.20; 95% CI 1.88-2.58). These were almost unchanged when we excluded cases and controls who had been prescribed prednisolone. We found no association with hypercholesterolaemia or gout, nor with smoking status or socio-economic status. CONCLUSIONS: The study provides further evidence of an association between idiopathic pulmonary fibrosis and both diabetes mellitus and gastro-oesophageal reflux. |
|---|
| ジャーナル名 | Respiratory medicine |
|---|
| 投稿日 | 2008/12/09 |
|---|
| 投稿者 | Gribbin, Jonathan; Hubbard, Richard; Smith, Chris |
|---|
| 組織名 | Division of Epidemiology and Public Health, University of Nottingham, Respiratory;Medicine, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham;NG5 1PB, UK. mcxjg@nottingham.ac.uk |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/19058956/ |
|---|
