| アブストラクト | BACKGROUND: Atopic dermatitis is known to be common among children, but there are few studies examining the epidemiology across the life course. In particular, there is a paucity of data on atopic dermatitis among older adults. OBJECTIVE: To evaluate participant characteristics, patterns of disease activity and severity, and calendar trends in older adult atopic dermatitis in comparison to other age groups in a large population-based cohort. METHODS: This was a cohort study of 9,154,936 individuals aged 0-99 years registered in The Health Improvement Network, a database comprised of electronic health records from general practices in the United Kingdom between 1994 and 2013. Atopic dermatitis was defined by a previously validated algorithm using a combination of at least one recorded atopic dermatitis diagnostic code in primary care and two atopic dermatitis therapies recorded on separate days. Cross-sectional analyses of disease prevalence were conducted at each age. Logistic mixed effect regression models were used to identify predictors of prevalent disease over time among children (0-17 years), adults (18-74 years), and older adults (75-99 years). RESULTS: Physician-diagnosed atopic dermatitis was identified in 894,454 individuals with the following proportions in each age group: 18.3% of children, 7.7% of adults, and 11.6% of older adults. Additionally, atopic dermatitis prevalence increased across the 2-decade period (beta from linear regression test for trend in the change in proportion per year = 0.005, p = 0.044). In older adults, atopic dermatitis was 27% less common among females (adjusted OR 0.73, 95% CI 0.70-0.76) and was more likely to be active (59.7%, 95% CI 59.5-59.9%) and of higher severity (mean annual percentage with moderate and severe disease: 31.8% and 3.0%, respectively) than in other age groups. CONCLUSION: In a large population-based cohort, the prevalence of physician-diagnosed atopic dermatitis has increased throughout adulthood and was most common among males age 75 years and above. Compared to children ages 0-17 and adults ages 18-74, older adult atopic dermatitis was more active and severe. Because the prevalence of atopic dermatitis among older adults has increased over time, additional characterization of disease triggers and mechanisms and targeted treatment recommendations are needed for this population. |
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| ジャーナル名 | PloS one |
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| 投稿日 | 2021/10/7 |
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| 投稿者 | Chan, Leslie N; Magyari, Alexa; Ye, Morgan; Al-Alusi, Noor A; Langan, Sinead M; Margolis, David; McCulloch, Charles E; Abuabara, Katrina |
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| 組織名 | School of Medicine, University of California San Francisco, San Francisco,;California, United States of America.;University of California Berkeley, Berkeley, California, United States of;America.;Department of Dermatology, University of California San Francisco, San Francisco,;Department of Non-communicable Disease Epidemiology, London School of Hygiene and;Tropical Medicine, London, England, United Kingdom.;Department of Dermatology, Perelman School of Medicine, University of;Pennsylvania, Philadelphia, Pennsylvania, United States of America.;Department of Epidemiology and Biostatistics, University of California San;Francisco, San Francisco, California, United States of America. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/34614025/ |
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