| アブストラクト | INTRODUCTION: Idiopathic intracranial hypertension (IIH) is known to elevate cardiovascular disease (CVD) risk, but the extent to which obesity and IIH-specific factors contribute to this risk is not well understood. WE aim to separate the effects of obesity from IIH-specific factors on the risk of stroke and CVD, building on previous findings that indicate a two-fold increase in cardiovascular events in women with IIH compared to BMI-matched controls. METHODS: An obesity-adjusted risk analysis was conducted using Indirect Standardization based on data from a cohort study by Adderley et al., which included 2,760 women with IIH and 27,125 matched healthy controls from The Health Improvement Network (THIN). Advanced statistical models were employed to adjust for confounding effects of obesity and determine the risk contributions of IIH to ischemic stroke and CVD, independent of obesity. Four distinct models explored the interactions between IIH, obesity, and CVD risk. RESULTS: The analysis showed that IIH independently contributes to increased cardiovascular risk beyond obesity alone. Risk ratios for cardiovascular outcomes were significantly higher in IIH patients compared to controls within similar obesity categories. Notably, a synergistic effect was observed in obese IIH patients, with a composite CVD risk ratio of 6.19 (95% CI: 4.58-8.36, p<0.001) compared to non-obese controls. CONCLUSIONS: This study underscores a significant, independent cardiovascular risk from IIH beyond obesity. The findings advocate for a shift in managing IIH to include comprehensive cardiovascular risk assessment and mitigation. Further research is required to understand the mechanisms and develop specific interventions for this group. |
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| 投稿者 | Azzam, Ahmed Y; Morsy, Mahmoud M; Ellabban, Mohamed Hatem; Morsy, Ahmed M; Zahran, Adham Adel; Nassar, Mahmoud; Elsayed, Omar S; Elswedy, Adam; Elamin, Osman; Al Zomia, Ahmed Saad; Abukhadijah, Hana J; Alotaibi, Hammam A; Atallah, Oday; Azab, Mohammed A; Essibayi, Muhammed Amir; Dmytriw, Adam A; Morsy, Mohamed D; Altschul, David J |
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| 組織名 | Faculty of Medicine, October 6 University, 6 of October City, Giza, Egypt.;Montefiore-Einstein Cerebrovascular Research Lab, Albert Einstein College of;Medicine, Bronx, NY, USA.;Director of Clinical Research and Clinical Artificial Intelligence, American;Society for Inclusion, Diversity, and Health Equity (ASIDE), Delaware, USA.;Clinical Research Fellow, American Society for Inclusion, Diversity, and Health;Equity (ASIDE), Delaware, USA.;Faculty of Medicine, Al-Azhar University, Cairo, Egypt.;Kasr Alainy Faculty of Medicine, Cairo University Hospitals, Cairo University,;Cairo, Egypt.;Department of Medicine, Division of Endocrinology, Diabetes and Metabolism,;Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, New;York, USA.;Founder, American Society for Inclusion, Diversity, and Health Equity (ASIDE),;Delaware, USA.;Department of Neurosurgery, Jordan Hospital, Amman, Jordan.;College of Medicine, King Khalid University, Abha, Saudi Arabia.;Medical Research Center, Hamad Medical Corporation, Doha, Qatar.;Ophthalmology Department, Prince Sultan Military Medical City, Riyadh, Saudi;Arabia.;Department of Neurosurgery, Hannover Medical School, Hannover, Germany.;Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, OH, USA.;Department of Neurological Surgery, Montefiore Medical Center, Albert Einstein;College of Medicine, Bronx, NY, USA.;Neuroendovascular Program, Massachusetts General Hospital & Brigham and Women's;Hospital, Harvard University, Boston, MA, USA.;Neurovascular Centre, Divisions of Therapeutic Neuroradiology & Neurosurgery, St.;Michael's Hospital, University of Toronto, Toronto, ON, Canada. |
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