| アブストラクト | BACKGROUND: Vitamin D has attracted considerable interest in recent years, and health care providers have reported large increases in vitamin D test requests. However, rates of diagnosis of vitamin D deficiency in clinical practice have not been investigated. We examined trends in diagnosis of vitamin D deficiency in children in England over time, and by sociodemographic characteristics. METHODS: Cohort study using primary care records of 711 788 children aged 0 to 17 years, from the Health Improvement Network database. Incidence rates for diagnosis of vitamin D deficiency were calculated per year between 2000 and 2014. Rate ratios exploring differences by age, sex, ethnicity, and social deprivation were estimated using multivariable Poisson regression. RESULTS: The crude rate of vitamin D deficiency diagnosis increased from 3.14 per 100 000 person-years in 2000 (95% confidence interval [CI], 1.31-7.54) to 261 per 100 000 person-years in 2014 (95% CI, 241-281). After accounting for changes in demographic characteristics, a 15-fold (95% CI, 10-21) increase in diagnosis was seen between 2008 and 2014. Older age (>/=10 years), nonwhite ethnicity, and social deprivation were independently associated with higher rates of diagnosis. In children aged <5 years, diagnosis rates were higher in boys than girls, whereas in children aged >/=10 they were higher in girls. CONCLUSIONS: There has been a marked increase in diagnosis of vitamin D deficiency in children over the past decade. Future research should explore the drivers for this change in diagnostic behavior and the reasons prompting investigation of vitamin D status in clinical practice. |
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| ジャーナル名 | Pediatrics |
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| Pubmed追加日 | 2017/2/6 |
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| 投稿者 | Basatemur, Emre; Horsfall, Laura; Marston, Louise; Rait, Greta; Sutcliffe, Alastair |
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| 組織名 | Population, Policy and Practice Programme, UCL Institute of Child Health, London,;United Kingdom; and emre.basatemur@ucl.ac.uk.;Research Department of Primary Care and Population Health, University College;London, London, United Kingdom.;United Kingdom; and. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/28159871/ |
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