| アブストラクト | OBJECTIVE: To investigate trends in the incidence of testing for vitamin D deficiency and the prevalence of patients with circulating concentrations of 25-hydroxyvitamin D (25(OH)D) indicative of deficiency (<30 nmol/L) between 2005 and 2015. DESIGN: Longitudinal analysis of electronic health records in The Health Improvement Network primary care database. SETTING: UK primary care. INTERVENTION: None. PARTICIPANTS: The analysis included 6 416 709 participants aged 18 years and older. PRIMARY OUTCOMES: Incidence of having a blood test for vitamin D deficiency between 2005 and 2015, the prevalence with blood 25(OH)D <30 nmol/L and the effects of age, ethnicity and socioeconomic status on these measures were assessed. RESULTS: After a mean follow-up time of 5.4 (SD 3.7) years, there were 210 502 patients tested for vitamin D deficiency. The incidence of vitamin D testing rose from 0.29 per 1000 person-years at risk (PYAR) (95% CI 0.27 to 0.31) in 2005 to 16.1 per 1000 PYAR (95% CI 15.9 to 16.2) in 2015. Being female, older, non-white ethnicity and more economically deprived were all strongly associated with being tested. One-third (n=69 515) had 25(OH)D <30 nmol/L, but the per cent deficient among ethnic minority groups ranged from 43% among mixed ethnicity to 66% in Asians. Being male, younger and more economically deprived were also all associated with vitamin D deficiency (p<0.001). CONCLUSIONS: Testing for vitamin D deficiency increased over the past decade among adults in the UK. One-third of UK adults who had a vitamin D test performed in primary care were vitamin D deficient, and deficiency was much higher among ethnic minority patients. Future research should focus on strategies to ensure population intake of vitamin D, particularly in at-risk groups, meets recommendations to reduce the risk of deficiency and need for testing. |
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| ジャーナル名 | BMJ open |
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| 投稿日 | 2019/6/7 |
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| 投稿者 | Crowe, Francesca L; Jolly, Kate; MacArthur, Christine; Manaseki-Holland, Semira; Gittoes, Neil; Hewison, Martin; Scragg, Robert; Nirantharakumar, Krishnarajah |
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| 組織名 | Institute of Applied Health Research, University of Birmingham, Birmingham, UK.;Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham,;Birmingham, UK.;School of Population Health, The University of Auckland, Auckland, New Zealand.;Institute of Metabolism and Systems, University of Birmingham, Birmingham, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/31167871/ |
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