| アブストラクト | OBJECTIVE: This study was conducted to determine if type 1 diabetes is associated with an increased risk of fracture across the life span. RESEARCH DESIGN AND METHODS: This population-based cohort study used data from The Health Improvement Network (THIN) in the U.K. (data from 1994 to 2012), in which 30,394 participants aged 0-89 years with type 1 diabetes were compared with 303,872 randomly selected age-, sex-, and practice-matched participants without diabetes. Cox regression analysis was used to determine hazard ratios (HRs) for incident fracture in participants with type 1 diabetes. RESULTS: A total of 334,266 participants, median age 34 years, were monitored for 1.9 million person-years. HR were lowest in males and females age <20 years, with HR 1.14 (95% CI 1.01-1.29) and 1.35 (95% CI 1.12-1.63), respectively. Risk was highest in men 60-69 years (HR 2.18 [95% CI 1.79-2.65]), and in women 40-49 years (HR 2.03 [95% CI 1.73-2.39]). Lower extremity fractures comprised a higher proportion of incident fractures in participants with versus those without type 1 diabetes (31.1% vs. 25.1% in males, 39.3% vs. 32% in females; P < 0.001). Secondary analyses for incident hip fractures identified the highest HR of 5.64 (95% CI 3.55-8.97) in men 60-69 years and the highest HR of 5.63 (95% CI 2.25-14.11) in women 30-39 years. CONCLUSIONS: Type 1 diabetes was associated with increased risk of incident fracture that began in childhood and extended across the life span. Participants with type 1 diabetes sustained a disproportionately greater number of lower extremity fractures. These findings have important public health implications, given the increasing prevalence of type 1 diabetes and the morbidity and mortality associated with hip fractures. |
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| ジャーナル名 | Diabetes care |
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| Pubmed追加日 | 2015/7/29 |
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| 投稿者 | Weber, David R; Haynes, Kevin; Leonard, Mary B; Willi, Steven M; Denburg, Michelle R |
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| 組織名 | Golisano Children's Hospital, University of Rochester School of Medicine and;Dentistry, Rochester, NY david_weber@urmc.rochester.edu.;Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.;Stanford University School of Medicine, Stanford, CA.;Children's Hospital of Philadelphia, Perelman School of Medicine at the;University of Pennsylvania, Philadelphia, PA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/26216874/ |
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