| アブストラクト | PURPOSE: Pharmacoepidemiology researchers often utilize data from two UK electronic medical record databases, the Clinical Practice Research Datalink (CPRD) and The Health Improvement Network (THIN), and may choose to combine the two in an effort to increase sample size. To minimize duplication of data, previous studies examined the practice-level overlap between these databases. However, the proportion of overlapping patients remains unknown. We developed a method using demographic and pharmacy variables to identify patients included in both CPRD and THIN, and applied this method to measure the proportion of overlapping patients who initiated the oral anti-diabetic drug saxagliptin. METHODS: We conducted a cross-sectional study among patients initiating saxagliptin in CPRD and THIN between October 2009 and September 2012. Within both databases, we identified patients: (i) >/=18 years, (ii) newly prescribed saxagliptin, and (iii) with >/=180 days enrollment prior to saxagliptin initiation. Demographic data (birth year, sex, patient registration date, family number, and marital status) and prescriptions (including dates) for the first two oral anti-diabetic drugs prescribed within the study period were used to identify matching patients. RESULTS: Among 4202 CPRD and 3641 THIN patients initiating saxagliptin, 2574 overlapping patients (61% of CPRD saxagliptin initiators; 71% of THIN saxagliptin initiators) were identified. Among these patients, 2474 patients (96%) perfectly matched on all demographic and prescription data. CONCLUSIONS: Within each database, over 60% of patients initiating saxagliptin were included within both CPRD and THIN. Combined demographic and prescription data can be used to identify patients included in both CPRD and THIN. |
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| ジャーナル名 | Pharmacoepidemiology and drug safety |
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| 投稿日 | 2015/07/28 |
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| 投稿者 | Carbonari, Dena M; Saine, M Elle; Newcomb, Craig W; Blak, Betina; Roy, Jason A; Haynes, Kevin; Wood, Jennifer; Gallagher, Arlene M; Bhullar, Harshvinder; Cardillo, Serena; Hennessy, Sean; Strom, Brian L; Lo Re, Vincent 3rd |
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| 組織名 | Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics;and Epidemiology, Perelman School of Medicine at the University of Pennsylvania,;Philadelphia, PA, USA.;Center for Pharmacoepidemiology Research and Training, Department of;Biostatistics and Epidemiology, Perelman School of Medicine at the University of;Pennsylvania, Philadelphia, PA, USA.;AstraZeneca UK Limited, London, UK.;HealthCore, Inc., Wilmington, DE, USA.;Department of Global Pharmacovigilance and Epidemiology, Bristol-Myers Squibb,;Hopewell, NJ, USA.;Clinical Practice Research Datalink, London, UK.;IMS Health, London, UK.;Department of Medicine, Perelman School of Medicine at the University of;Rutgers Biomedical and Health Sciences, Rutgers, the State University of New;Jersey, Newark, NJ, USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/26213344/ |
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