| アブストラクト | BACKGROUND: Vitiligo patients often report their mental health has an effect on their skin. However, it is unknown as to whether a common mental disorder, such as major depressive disorder (MDD), can also precipitate the onset of vitiligo. OBJECTIVE: Evaluate a bidirectional relationship between MDD and vitiligo using The Health Improvement Network database. METHODS: Incident MDD and referent cohorts were followed until the development of vitiligo. Also, incident vitiligo and referent cohorts were followed until the development of MDD. Cox proportional hazards models were used, and numerous covariates were adjusted for. RESULTS: In adjusted models, MDD patients (n = 405,397) were at a 64% increased risk for vitiligo (hazard ratio 1.64, 95% confidence interval [CI] 1.43-1.87, P < .0001) compared with the referent cohort (n = 5,739,048). This risk was decreased in patients using antidepressants. Compared with the referent cohort (n = 6,137,696), patients with vitiligo (n = 7104) that were <30 years of age at diagnosis had a higher risk of developing MDD than patients >/=30 years of age (hazard ratio 1.31, 95% CI 1.14-1.50, P < .0001 vs 1.22, 95% CI 1.08-1.37, P = .001, respectively). LIMITATIONS: This study did not evaluate the severity of MDD or vitiligo on outcome development. CONCLUSION: These results highlight the burden of depression in patients with vitiligo and support the possible existence of pathophysiological connections between these 2 conditions. |
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| ジャーナル名 | Journal of the American Academy of Dermatology |
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| 投稿日 | 2018/12/12 |
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| 投稿者 | Vallerand, Isabelle A; Lewinson, Ryan T; Parsons, Laurie M; Hardin, Jori; Haber, Richard M; Lowerison, Mark W; Barnabe, Cheryl; Patten, Scott B |
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| 組織名 | Department of Community Health Sciences, Cumming School of Medicine, University;of Calgary, Calgary, Canada. Electronic address: ivall@ucalgary.ca.;Division of Dermatology, Cumming School of Medicine, University of Calgary,;Calgary, Canada.;of Calgary, Calgary, Canada; Clinical Research Unit, Cumming School of Medicine,;University of Calgary, Calgary, Canada.;of Calgary, Calgary, Canada; Department of Medicine, Cumming School of Medicine,;of Calgary, Calgary, Canada; Department of Psychiatry, Cumming School of;Medicine, University of Calgary, Calgary, Canada. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/30528503/ |
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