論文・技術情報追加のお知らせ

1. Assessing safety concerns of interstitial lung disease associated with antibody-drug conjugates: a real-world pharmacovigilance evaluation of the FDA adverse event reporting system.

抗体薬物複合体による肺間質疾患の安全信号を調査

対象DB：FAERS

2. Comparative study on the occurrence of adverse effects in the concomitant use of azathioprine and aldehyde oxidase inhibitors.

アザチオプリンとアルデヒド酸化酵素阻害剤の薬物相互作用が血液および肝障害に及ぼす影響を検討

対象DB：FAERS,JADER

3. Frequency and Risk Factor Analysis for Metronidazole-Associated Neurologic Adverse Events.

メトロニダゾール関連の神経障害のリスク要因と頻度を調査

対象DB：FAERS,KAERS

4. The association between glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and suicidality: reports to the Food and Drug Administration adverse event reporting system (FAERS).

GLP-1受容体作動薬に関連する自殺念慮やうつ病についてFAERSデータを評価

対象DB：FAERS

5. High risks adverse events associated with usage of aspirin in chronic obstructive pulmonary disease.

慢性閉塞性肺疾患患者におけるアスピリン使用の副作用をFAERSデータから調査

対象DB：FAERS

6. Stacking Ensemble of Disproportionality Indicators for Adverse Vaccine Reactions Detection-An Empirical Study on Predicting Adverse Reactions of COVID-19 Vaccines.

COVID-19ワクチンの副反応検出に新しい手法提案

対象DB：FAERS,VAERS

7. The association between ACE inhibitors and psoriasis based on the drug-targeted Mendelian randomization and real-world pharmacovigilance analyses.

ACE阻害剤の遺伝的影響と乾癬の因果関係についてメンデルのランダム化解析

対象DB：FAERS

8. Myocarditis and pericarditis in individuals exposed to the Ad26.COV2.S, BNT162b2 mRNA, or mRNA-1273 SARS-CoV-2 vaccines.

COVID-19ワクチン接種後の心筋炎および心膜炎の報告率を評価

対象DB：FAERS,VAERS

9. Adverse events in patients with advanced urothelial carcinoma treated with erdafitinib: a retrospective pharmacovigilance study.

FAERSを用いたerdafitinibに関連する有害事象の評価

対象DB：FAERS

10. Model driven method for exploring individual and confounding effects in spontaneous adverse event reporting databases.

FAERSデータの解釈における課題をMD-RORで検討

対象DB：FAERS

11. Multiple myeloma, haematologic malignancy and immunosuppressant and immunomodulatory medications are associated with sebaceous carcinoma, a pharmacovigilance study of the FDA adverse event reporting system.

脂腺癌と免疫抑制薬の関連性

対象DB：FAERS

12. Drug-induced Acute Pancreatitis: A Real-world Pharmacovigilance Study Using the FDA Adverse Event Reporting System Database.

薬剤誘発急性膵炎の主な原因薬としてのメトホルミンの研究

対象DB：FAERS

13. Postmarket safety profile of suicide/self-injury for GLP-1 receptor agonist: a real-world pharmacovigilance analysis.

FAERSにおけるGLP-1RAによる自殺や自傷行為のリスク

対象DB：FAERS

14. Interstitial lung disease following COVID-19 vaccination: a disproportionality analysis using the Global Scale Pharmacovigilance Database (VigiBase).

COVID-19ワクチン接種後の間質性肺疾患シグナルの検討

対象DB：VigiBase

15. Lifestyle factors associated with a rapid decline in the estimated glomerular filtration rate over two years in older adults with type 2 diabetes-Evidence from a large national database in Japan.

2型糖尿病患者の急速なeGFR低下とライフスタイルの研究

対象DB：NDB

16. Relationship between antihypertensive drug use and number of people with high blood pressure in FY 2018: a descriptive epidemiological study based on the National Database of Health Insurance Claims and Specific Health Checkups of Japan open data.

高血圧治療薬の処方量が血圧数を指標化

対象DB：NDB

17. Benefit of Prompt Vs Delayed Initiation of Triple Therapy Following an Exacerbation in Patients with COPD in Japan: A Retrospective Cohort Study.

慢性閉塞性肺疾患患者における三重療法の早期導入と、クリニカルおよび経済的成果の検討

対象DB：MDV

18. Prevalence, Incidence, and Clinical Characteristics of Thyroid Eye Disease in Japan.

日本における甲状腺眼症（TED）の発症率

対象DB：MDV

19. Clinical features of acute attacks, chronic symptoms, and long-term complications among patients with acute hepatic porphyria in Japan: a real-world claims database study.

日本の急性肝性ポルフィリン症患者の臨床的特徴：急性発作、慢性症状、長期合併症の高い負担

対象DB：MDV

20. Phenotypes and rates of cancer-relevant symptoms and tests in the year before cancer diagnosis in UK Biobank and CPRD Gold.

がん患者の事前症状の電子健康記録の比較

対象DB：CPRD

21. Clinical risk associated with COVID-19 among 86000 patients with congenital heart disease.

COVID-19感染患者の先天性心疾患(CHD)患者のリスクを調査

対象DB：CPRD

22. Clinically apparent Helicobacter pylori infection and the risk of incident Alzheimer's disease: A population-based nested case-control study.

ヘリコバクター・ピロリ感染とアルツハイマー病のリスクの関連性を評価

対象DB：CPRD

23. Real-world study of the concomitant use of biphasic insulin as part 30/70 with GLP-1 receptor agonist versus first-generation basal insulin with GLP-1 receptor agonist in type 2 diabetes.

英国の臨床実務データを用いた糖尿病治療の研究

対象DB：CPRD

24. Regional variations and deprivation are linked to poorer access to laparoscopic and robotic colorectal surgery: a national study in England.

2006年から2020年までの英国における大腸手術データを分析

対象DB：CPRD

25. Predicting risk of endometrial cancer in asymptomatic women (PRECISION): Model development and external validation.

45-60歳の女性を対象に、子宮内膜がんのリスク予測モデルを開発

対象DB：CPRD

26. Impact of pregnancy vaccine uptake and socio-demographic determinants on subsequent childhood Measles, Mumps and Rubella vaccine uptake: A UK birth cohort study.

母子電子記録を使用し、MMRワクチン接種率に対する社会人口統計の影響を検証

対象DB：CPRD

27. Risk of atrial fibrillation and association with other diseases: protocol of the derivation and international external validation of a prediction model using nationwide population-based electronic health records.

心房細動発症予測のためランダムフォレストと多変量ロジスティック回帰をCPRD-GOLDデータセットで実施

対象DB：CPRD

28. Resource utilisation and outcomes of people with heart failure in England: a descriptive analysis of linked primary and secondary care data - the PULSE study.

英国の心不全患者の医療リソース利用と死亡率を調査

対象DB：CPRD

29. Validation and comparison of the coding algorithms to identify people with migraine using Japanese claims data.

片頭痛特定のためのコーディングアルゴリズムの検証と比較

対象DB：DeSC